Introducing lecture - Linear ubiquitination in cell death and inflammation
Prof. Henning Walczak - University College London, United Kingdom
›15:00 (2h30)
Apoptotic signalling and resistance Chairpersons: Dr. Catherine Pellat-Deceunynck (Nantes, France), Dr. Patrick Legembre (Rennes, France), Dr. Olivier Micheau (Dijon, France)
15:00 - 17:30 (2h30)
Apoptotic signalling and resistance
Chairpersons: Dr. Catherine Pellat-Deceunynck (Nantes, France), Dr. Patrick Legembre (Rennes, France), Dr. Olivier Micheau (Dijon, France)
› Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia - Lingli Yuan, INSERM UMR 1037, Centre de recherches en cancérologie de Toulouse, France
15:00-15:20 (20min)
› Vitamin D3 and lenalidomide synergize to induce apoptosis in mantle cell lymphoma via unmethylation of BIK - Carole Brosseau, Institut de Recherche en Santé de l'Université de Nantes, France
15:20-15:40 (20min)
› Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in vivo - Ophélie MEYNET, INSERM U1065, Centre Méditerranéen de Médecine Moléculaire, Nice, France
15:40-16:00 (20min)
› Trim17, a novel E3 ubiquitin-ligase for the anti-apoptotic protein Mcl-1 - Solange DESAGHER, Institut de génétique moléculaire de Montpellier, France
16:30-16:50 (20min)
› Therapeutic interest to target the Phosphoinositide-3-Kinase (PI3K) – mTOR (Target Of Rapamycin) pathway in pancreatic Cancer-Associated Fibroblasts - Camille Duluc, INSERM UMR 1037, Centre de Recherches en Cancérologie de Toulouse, France
16:50-17:10 (20min)
› Chemosensitization of pancreatic cancer cells using gene transfer: from the proof of concept to phase I clinical trial - Pierre Cordelier, INSERM U1037, Centre de Recherches en Cancérologie de Toulouse, France
17:10-17:30 (20min)
